Vilamaniscle (Catalan pronunciation: [ˌbiləməˈnisklə]) is a municipality in the comarca of Alt Empordà, Girona, Catalonia, Spain.

It is located in the western part of the Serra de la Baga d'en Ferràn, a branch of the Albera Range.

Much of its municipal term is covered with pine and cork oak trees.

Vilamaniscle is dominated by the "Castell", a three-level unrestored building whose origin is difficult to date.

In the prehistoric time people probably lived here, the evidence being the three-metres-high menhir "Pedra Dreta" which is very close to Vilamaniscle.