A Latin inscription on the facade (Angelus Calidonius Luschi Filius MDLXX) dates the completion of the building to 1570 when it belonged to Angelo Caldogno.

The villa is not included in I quattro libri dell'architettura, Palladio's treatise of 1570, in which the architect discussed a number of his creations.

In 1932 the villa and the surrounding lands were purchased by Dr. Ettore Nordera, the director of the neurological medicine department of the hospital San Felice in Vicenza.

It was during this period in which some constructions were added behind the main villa between 1937-39 to accommodate more space for the clinic.

The Nordera Institute at the Villa Caldogno-Nordera would eventually close and in 1978 part of the property was given to the communal administration.