Villa DeSales, built in 1877–1878, is a large five-by-three bay, three-story frame High Victorian Gothic dwelling with a two-story south service wing, located at Aquasco, Prince George's County, Maryland.

The historic home is significant for its architectural character which includes a complex of six 19th century outbuildings.

The large size of the house, the decorative slate roof, amount and variety of cornice and gable trusses, brackets, and pendants; and the well preserved interior with original Gothic Revival-style lighting fixtures and parlor and bedroom furnishings make the house exceptional.

The Bowling and Forbes families were large landowners in southern Prince George's and neighboring Charles County, Maryland during the 19th century.

This article about a Registered Historic Place in Prince George's County, Maryland is a stub.