Villa San Secondo is a comune (municipality) in the Province of Asti in the Italian region Piedmont, located about 35 kilometres (22 mi) east of Turin and about 12 kilometres (7 mi) northwest of Asti.

Villa San Secondo borders the following municipalities: Castell'Alfero, Corsione, Cossombrato, Frinco, Montechiaro d'Asti, Montiglio Monferrato, and Tonco.

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