Husso made his North American debut with the Wolves against the Grand Rapids Griffins on 15 October 2016 to begin the 2016–17 season.

[12] By the end of the regular season he had taken over the starting position, which in turn raised questions about the future of the team's goaltending, as Binnington was signed to a lengthy and expensive contract while Husso was to become a free agent.

[13] The Blues qualified for the 2022 Stanley Cup playoffs, entering the first round as underdogs against the Minnesota Wild, with Husso starting in net.

[15][16] Husso served as backup until Binnington was injured during the second round series against the Colorado Avalanche, at which point he reclaimed the net.

[20] He made 29 saves in his regular season debut with Detroit on October 14, 2022, earning a shutout in a 3–0 victory over the Montreal Canadiens.

Husso was a member gold-winning of Team Finland at the 2014 World Junior Ice Hockey Championships, serving as a back-up goalie to Juuse Saros.