Villefranche-sur-Saône (US: /ˌviːl(ə)ˈfrɒ̃ʃ sʊər ˈsoʊn/,[3] French: [vilfʁɑ̃ʃ syʁ son] ⓘ; Arpitan: Velafranche) is a commune in the Rhône department in eastern France.

It lies 1 mile (1.6 km) west of the river Saône, and is around 25 kilometres (16 mi) north of Lyon.

The population data in the table and graph below refer to the commune of Villefranche-sur-Saône proper, in its geography at the given years.

The Autoroute du Sud (the principal road from Paris to the south of France) is adjacent to the east of the town, running alongside the Saône.

The church of Notre-Dame des Marais, begun at the end of the 14th and finished in the 16th century, has a tower and spire (rebuilt in 1862), standing to the right of the 15th century façade, in which are carved wooden doors.