Villers-le-Sec (French pronunciation: [vilɛʁ lə sɛk]) is a commune in the Meuse department in Grand Est in north-eastern France.

Its epithet "Sec" (dry) comes from the fact that no rivers pass through Villers-le-Sec, which is located on the plateau between the rivers Ornain and Saulx.

Villers-le-Sec had more than 500 inhabitants in the middle of the 19th century,[3] when an iron mine was operated near the village.

Forestry remains a significant resource today.

The only industry which remains today is a distillery, which produces mirabelle brandy during the low season.