He served as the head football coach at Western Illinois University from 1949 to 1953, at Iowa State University from 1954 to 1956, and at Carroll College—now known as Carroll University—in Waukesha, Wisconsin from 1959 to 1971, compiling a career college football coaching record of 106–71–7.

[4] DiFrancesca also served as athletic director while he was head football coach.

[6] DiFrancesca died in May 2007 and was the father of both national radio talkshow host Janet Parshall of Janet Parshall's America and the late Charlie DiFrancesca, the subject of the book "Charlie Di: The Story of The Legendary Bond Trader", by William D.

DiFrancesca also had a wife Margret, who was a proud Icelandic, Baptist, Republican who converted Vince to her beliefs.

The Di Francesca family came from Italy, lived in Evanston, Illinois on Ashland Ave. Raised Roman Catholic, mother Elizabeth Farina Di Francesca and father Salvatore, "Sam".