He signed with Talib Kweli's Blacksmith Records prior to releasing his collaborative mixtape with Mac Miller, Stolen Youth (2013).

(2019), his self-titled fourth studio album (2021), and Ramona Park Broke My Heart (2022), each diversified his artistry, being met with continued critical acclaim and moderate commercial response.

[6] Staples' music is described as West Coast hip hop, often containing conscious subject matter while production experiments with avant-garde, dance and electronic influences.

[7] Outside of his solo career, he is a member of the California-based hip hop trio Cutthroat Boyz with Aston Matthews and Joey Fatts.

Staples has acted in the films Dope and White Men Can't Jump, and the television series Abbott Elementary.

Staples recalled playing against the Carson Colts and Mission Viejo Cowboys who he claimed had "grown-ass men on the field."

LaVish took Staples on a trip to Los Angeles, where he befriended the Odd Future collective's members Syd tha Kyd, Mike G, and Earl Sweatshirt.

The mixtape features guest appearances from Miller, Ab-Soul, Schoolboy Q, Da$H, Hardo, and Staples's Cutthroat Boyz co-member Joey Fatts.

[18] The mixtape features the production from Earl Sweatshirt, Michael Uzowuru, Childish Major, No ID, Evidence,[11] DJ Babu, and Scoop DeVille; as well as guest appearances from singer-songwriters Jhené Aiko and James Fauntleroy.

[24] Prior to the EP's release Staples revealed during an interview with XXL Magazine that it would include guest appearances from Aston Matthews and Teyana Taylor, along with productions from No I.D., Infamous, and Hagler.

He later announced it that his debut studio album would be titled Summertime '06.,[26] In June 2015, Staples was named as one of the ten rappers of XXL's "2015 Freshman Class".

Staples collaborated with film composer Hans Zimmer on a remix of the UEFA Champions League Anthem for the FIFA 19 reveal trailer.

[41] In 2018, Staples set up a GoFundMe page titled "Get the Fuck Off My Dick" seeking $2 million as a response to people criticizing his work; they could pay to have him retire early.

[43] Additionally, Staples contributed the song "Home" to the Spider-Man: Into the Spider-Verse soundtrack, which was originally previewed in the movie's trailer in December 2017.

", "Sheet Music", and "Ad 01: Hell Bound", each accompanied by an episode of his YouTube series The Vince Staples Show.

The album delves into Staples' relationship with his Long Beach neighborhood, Ramona Park, blending personal narratives with broader social commentary.

[54] On June 14, 2016, Staples announced his assistance in a YMCA program that will benefit young people in North Long Beach.

[55][56][57] The majority of Staples' family are immigrants from Haiti, who had first arrived in Eastern Canada, then left for Louisiana believing that they could buy land cheaper but were unaware of the social economic climate there at the time.

[58] Growing up, Staples spent a lot of time with his maternal grandfather, Andrew Hutchins, a retired truck driver and construction worker who was a young boy when he arrived in the United States.

[61] He is a fan of modern art and has referenced the French-American sculptor Louise Bourgeois in his song "Rain Come Down" and stated his appreciation for painter and photographer Richard Prince.