Born on 30 August 1770 in Capodimonte in the Papal States, he studied in Montefiascone and in Rome and was ordained a priest in 1794.

In 1818 he was appointed Archbishop of Nisibi in partibus and from late 1818 to October 1819 was in Lucerne as Nuncio to the Swiss Confederation.

In the years 1819-1826 he was Nuncio in Paris, and was made Cardinal by Pope Leo XII in the consistory of 2 October 1826.

Although considered a candidate in the Papal conclave of 1830-1, his backing was insufficient, despite the support of Giuseppe Albani.

John and Paul, on the Coelian Hill, at the time of his death he was the last surviving cardinal elevated by Pope Leo XII.