The uprising preceded by a protest of revolutionary soldiers from quartered in Vinnytsia the 15 Reserve Infantry Regiment.
On 5 November (23 October) they came out on demonstration of protest against the order of command of the Southwestern Front to dissolve the regiment.
The same day on the initiative of Bolsheviks of the Vinnytsia Soviet workers and soldiers deputies there was created a revolutionary committee (revkom) headed by a leader of local Bolsheviks Nikolai Tarnogorodsky.
The committee also agreed not to allow departing to the frontlines the 15th regiment and other revolutionary minded formations that were located in Vinnytsia as well as prohibited to issue arms from the military warehouses.
However to their help from Zhmerynka arrived two regiments of the 2nd Guard Corps that drove the punishers out of Vinnytsia.