[4][5] David (Gabriel Soto) loses his wife Lisa (Laura Carmine) in a seemingly unintentional accident, perpetrated by her obsessive sister Graciela (Kimberly Dos Ramos).

His sinister mother-in-law Lilian (Azela Robinson) and supposed best friend Juan (Christian de la Campa) try to take advantage of the situation to steal David's fortune.

This was caused by Lilian, whose goal was to get rid of the entire family, especially Luciana's mother Marta (Cynthia Klitbo), for revenge of past troubles, as she sent officials after them despite having their documents in order and were in progress of becoming U.S. citizens.

[7] The development of Vino el amor is based on the Mexican emigration to the United States in search of "the American dream" and how these are humiliated and offended by the police and heartless people.

[12] On June 8, 2016, José Alberto Castro confirmed Kimberly Dos Ramos and Christian de la Campa as the main antagonists; both actors had an exclusive contract with Telemundo, and therefore they decided to accept Televisa's job offer.