Her film debut was alongside her father in Quattro bravi ragazzi (1993), and later took part in Jack Frusciante Left the Band.

Placido's other movies include Ora o mai più, by Lucio Pellegrini, Che ne sarà di noi, by Giovanni Veronesi, and Ovunque sei, directed by her father.

The TV series stars Chris Vance taking over the role of Frank Martin from Jason Statham.

In 2006, Placido released, under the name Viola, her first album as a singer, Don't Be Shy..., including 10 tracks she wrote (most of which are in English), inspired by Stuart Benson.

Subsequently, she collaborated with the Italian singer-songwriter Bugo in the remake duet version of his song "Amore mio infinito".