She toured with Margaret Anglin and portrayed the role of "Flora" in the original company of The Clansman.

She found success with these roles and was often cast as innocent young helpless girls which was a popular staple in films at the time.

[6] In 1916, Carl Laemmle decided to open one of his eastern United States studios for Mersereau's own productions.

Among her most successful ventures for Blue Bird and Universal include The Boy Girl (1917), Morgan's Raiders (1918), Little Miss Nobody (1917), Susan's Gentleman (1917), The Honor of Mary Blake (1916), Souls United (1917), Autumn (1916), and The Little Terror (1917).

she continued in motion pictures into the 1920s with her final film being The Wives of the Prophet (1926), in which she had the role of Alma.