The league existed from January 1922 to December 1936, though it did not start organizing athletic competitions and enforcing eligibility requirements until the beginning of the 1923 football season.
[3][4] By April 1923, it was reported that the remaining North Carolina colleges were unlikely to join, as there was a separate movement of their own to organize; Such an effort was spearheaded by Robert Lee Flowers of Trinity, but appears to have not come to fruition.
Following the 1923 football season, Lynchburg left the conference over an eligibility dispute, but was reinstated less than a week later after the situation was explained and remediation offered.
[9] Finally, the conference bowed to the desires of the larger schools, banning freshmen from intercollegiate athletics by the start of the 1928 football season.
[13][14] Aside from Lynchburg College electing to drop intercollegiate football in the summer of 1932, the Virginia Conference went through a period of relative stability following the departure of the Carolina schools.
First, the conference voted to re-allow the invitation of members outside of Virginia, namely St. John's (MD) and American University, both from the neighboring Baltimore area.