SR 154 heads north as an extension of Durant Road, a four-lane divided highway that parallels a rail spur to a manufacturing plant in the southern part of the city.

The state highway heads northeast as Riverside Drive through a residential area one block west of Main Street and to the east of the parallel Jackson River.

At the north end of the downtown area, SR 154 intersects US 60 (Monroe Avenue) just east of the U.S. Highway's bridge over the Jackson River at its confluence with Dunlap Creek.

The state highway passes under CSX's Alleghany Subdivision on the opposite side of the river from the WestRock factory complex.

SR 154 intersects another rail spur at an oblique angle, then turns east onto Hickory Street to reach its northern terminus at US 220 (Alleghany Avenue).