She began her career as a production assistant for television presenters, including Thierry Ardisson, Guillaume Durand and Michel Drucker.
She joined the channel to host with Olivier Minne special evening shows like La Saint Valentin en chansons.
In 2008, Virginie Guilhaume joined M6 where she presented in August a program dedicated to the jet set titled Stars et Fortunes.
In this program broadcast live just after Rendez-vous en terre inconnue, the guest personality talks about the most significant moments of his experience.
In July 2013, she presented the first season of the professional pastry contest Qui sera le prochain grand pâtissier ?
In May 2015, she is the spokesperson for France in the Eurovision Song Contest 2015, which took place in Vienna, announcing directly from Paris the score given by the French jury.
The following month, at the eve of the Fête de la musique, she co-hosted the evening titled Du soleil et des tubes with Patrick Sébastien from Nice[7] and broadcast live on France 2.
[12] Virginie Guilhaume is engaged since 2007 to a humanitarian foundation Caméléon, that protects and rehabilitates young girls from Philippines victim of sexual abuse.
In 2010, she is one of the spokespersons of the Flamme Marie Claire, a caritative event for the schooling of disadvantaged little girls in the world that allows to raise funds by selling candles.