She began her career as an Ivory soap baby and child actress, appearing in John Waters' film Hairspray (1988), and continued to appear in minor roles in films before launching a music career with the alternative rock band Eve's Plum in 1991.

She is the youngest of three children born to Vita, a legal secretary, and Gerard Fitzpatrick, a communications executive.

[12][13] In 1988, Fitzpatrick made her screen debut under her real name in the John Waters feature film Hairspray as Amber Von Tussle, the bratty on-screen daughter of co-stars Debbie Harry and Sonny Bono.

In 1998, Fitzpatrick launched a pop music solo project as "Vitamin C" and signed an album deal with Elektra Records.

[7] Released in 1999, her debut solo album Vitamin C peaked on the Billboard 200 at number 29[18] and was certified Platinum by the RIAA.

In the February 2001 issue of Cosmopolitan magazine, Vitamin C was voted as one of the "Fun and Fearless Females" of the year.

[3] The 2001 video game EA Sports Triple Play featured Vitamin C as an animated baseball player.

[38][39] In 2005, Vitamin C's cover of "Voices Carry" by 'Til Tuesday was included on the soundtrack for the Disney movie Sky High.

[40] The same year, she wrote the song "We Are Gonna Happen" for Emma Roberts on the Unfabulous and More album.

Vitamin C wrote and produced a number of song's for the group's debut album, which included a cover of "Graduation (Friends Forever)".

[46] Vitamin C also wrote the song "One and the Same", a duet recorded by Demi Lovato and Selena Gomez for the Disney Channel Original Movie Princess Protection Program.

[4][48][49] In 2016, she appeared as a featured artist on Information Society's cover of "Don't You Want Me"; her vocals on the release were recorded in 2001.