Liuzzi competed in Formula One for Red Bull, Toro Rosso, Force India and HRT, scoring 26 championship points across six seasons.

Racing in the German Formula Three Championship, in 2002, he joined the Red Bull Junior Team however, he finished in only ninth place.

[10] Initially it seemed that he might be given the seat along with David Coulthard, but Red Bull chose Christian Klien,[11] leaving Liuzzi as the test driver.

[12] At the 2006 United States Grand Prix, he scored the team's first point, with an eighth-place finish after a race-long battle with Coulthard and Nico Rosberg.

He seemed likely to score his first points of the season at Canada, but instead he crashed into the infamous "Wall of Champions" at the exit of the final chicane.

He also faced constant speculation over keeping his seat, as the team openly courted both Sebastian Vettel and Champcar series champion Sébastien Bourdais.

After being denied a world championship point in Japan by a post-race time penalty, he drove what many consider the best race of his Formula One career in China.

Narrowly missing out on Q3 by qualifying 11th, he gained three places at the start, then overtook Mark Webber of the 'works' Red Bull team, as well as the BMW of Nick Heidfeld.

Throughout the race he kept pace with 5th-placed Jenson Button's Honda, and held off a late charge from Heidfeld to finish 6th and collect three points.

[20] On 3 September 2009, Force India released Fisichella so he could replace Luca Badoer at Ferrari, who had filled in for two races for injured driver Felipe Massa.

At the Canadian Grand Prix, Liuzzi qualified in a career-best sixth, which improved to fifth after Mark Webber's gearbox change.

He scored another point at Spa-Francorchamps, after Jaime Alguersuari was penalised post-race for gaining an advantage from cutting the Bus Stop chicane in the closing laps.

[22] However, despite rumours suggesting that Kubica wanted Liuzzi to be his replacement,[23] the team opted to employ Nick Heidfeld to fill the role instead.

For the Indian Grand Prix, he was replaced by Narain Karthikeyan, who took a race seat in front of his home fans alongside Daniel Ricciardo.

[27] In February 2012 it was announced that Narain Karthikeyan had been handed the final race seat; leaving Liuzzi without a drive.

In 2013, Liuzzi and Johnny Herbert mentored 6 contestants in a primetime ITV4 reality series, with the aim of taking players of the Gran Turismo videogames to the Dubai 24 Hour race as real drivers.