The church is an imposing Romanesque structure situated high on the hill which the city climbs, but it lacks much of the spectacular decoration with which it was originally adorned, thanks to an ill-advised sixteenth-century reconstruction.
The cathedral was at the height of its significance during the middle and end of the thirteenth century, when it and the attached Palazzo dei Papi di Viterbo was the home of the papal throne following its flight from Rome and prior to its resettlement in Avignon.
The cathedral as built in the twelfth century is east-facing and sits high on the hill with the attached Papal palace overlooking the town spread below.
Its façade oddly contrasts with surrounding buildings as it is not built from local stone, but was instead constructed with imported materials during Gambarra's reconstruction.
Only two notable early artworks survive, a Redentore benedicte (Christ giving a blessing) (1472) attributed to Gerolamo da Cremona[2] and a 12th-century Madonna and Child by an unknown artist; the work appears to be an earlier version of a famous painting in the Basilica di Santa Maria Maggiore in Rome.
To the south of the square, the House of Valentino della Pagnotta received a direct hit from an Allied bomb in World War Two but was reconstructed to original specifications.
The piazza boasts several small fountains and a number of other medieval buildings, but it is dominated on its north-facing side by the Palazzo dei Papi di Viterbo, which was enlarged and reconstructed in 1266 following the Papal move to the city.