Vitry-en-Perthois (French pronunciation: [vitʁi ɑ̃ pɛʁtwa]) is a commune in the Marne department in north-eastern France.

Vitry-en-Perthois was called Vitry-le-Brûlé (Vitry the burnt) after being burnt two times; in 1142 by the armies of Louis VII of France and in 1544 by the armies of Charles V. The Chée flows into the Saulx in the northern part of the commune.

The Saulx forms part of the commune's eastern border, then flows westward through the commune and crosses the village.

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