His father was Ioan Grigore Ghica, diplomat, minister plenipotentiary in Turkey; his mother Alexandrina was born Moret de Blaremberg (van Blarembergue) in a Flemish-Russian family; he had four brothers and a sister: Gregory, Alexander, George and Ella (who both died at an early age), and Dimitrie I. Ghika (future ambassador and minister of foreign affairs).

Ghika wanted to become a priest or monk, but Pius X advised him to give up the idea, at least for a while, and to dedicate himself to secular apostolate instead.

After returning to Romania, he dedicated himself to works of charity and opened the first free clinic in Bucharest called Mariae Bethlehem.

He was dedicated to patient care while participating in health services in the Balkan War in 1913, without the fear of cholera in Zimnicea.

During World War I, he was also in charge of diplomatic missions among the victims of the Avezzano earthquake who were suffering from tuberculosis in the Hospice of Rome.

He worked worldwide, including Bucharest, Rome, Paris, Congo, Tokyo, Sydney, and Buenos Aires, among others.

He refused to leave Romania at that time so that he could be with the poor and sick, and he did so even when the Allies began bombing Bucharest, where he lived.

[3] Ghika was proposed for beatification by the Archdiocese of Bucharest, based on a dossier with his biography submitted to the Congregation for the Causes of Saints in the Vatican.

His short personal meditations were subsequently published in various editions as Pensées pour la suite des jours.