Vlagtwedde (Dutch pronunciation: [ˈvlɑxˌtʋɛdə] ⓘ) is a village in the very southeast of Groningen province in the northeastern Netherlands.

It lies on the Dutch border with the German state of Lower Saxony to the east.

[5] The population centres in the municipality of Vlagtwedde were: Abeltjeshuis, Bakovensmee, Barnflair, Borgertange, Borgerveld, Bourtange, Burgemeester Beinsdorp, De Bruil, Ellersinghuizen, Hanetange, Harpel, Hasseberg, Hebrecht, 't Heem, Jipsingboermussel, Jipsingboertange, Jipsinghuizen, Lammerweg, Laude, Lauderbeetse, Laudermarke, Lauderzwarteveen, Leemdobben, Maten, Munnekemoer, Over de Dijk, Overdiep, Pallert, Plaggenborg, Poldert, Renneborg, Rhederveld, Rijsdam, Roelage, 't Schot, Sellingen, Sellingerbeetse, Sellingerzwarteveen, Slegge, Stakenborg, Stobben, Ter Apel, Ter Apelkanaal, Ter Borg, Ter Haar, Ter Walslage, Ter Wisch, Veele, Veerste Veldhuis, Vlagtwedde, Vlagtwedder-Barlage, Vlagtwedder-Veldhuis, Weende, Weenderveld, Weite, Wessingtange, Wollingboermarke, Wollinghuizen, Zandberg and Zuidveld.

Because of the large number of official centres, the municipality had five postal codes: All 60 villages and hamlets in the municipality received their own town sign in 2008.

[6] There was an election in November 2017 for the council of the new merged Westerwolde municipality that commenced work on 1 January 2018, replacing Vlagtwedde council.