It flows through Crna Trava, regional and municipal center, and the villages of Brod, Krstićevo and Jabukovik, where it reaches the Lužnica mountain and receives the Gradska from the right.

After the villages of Batulovce and Stajkovce, the Vlasina empties into the South Morava, east of the Leskovac's eastern suburb of Mrštane.

[5][6] The river's valley, from the Vlasina Lake to the town of Vlasotince is narrow, defile-like with steep sides prone to heavy erosion.

After the negative backlash which followed construction of mini hydros in other parts of Serbia, and action of the local environmentalists, the municipality of Vlasotince banned such facilities on its territory in March 2021.

Extreme downpours and heavy storms affected river's watershed area in the municipalities of Vlasotince, Crna Trava, Babušnica, Pirot and Leskovac.

In Vlasotince, 1,700 buildings were flooded, 120 were completely destroyed, so as 55 artisan shops, while all major companies and economic organizations were disabled.

Apart from Vlastince, huge damage stroke the villages of Dobroviš, Tegošnica, Gornji Orah, Svođe, Dejan, Kruševica, Boljare, Manastirište, Konopnica and Stajkovce.

In the next period, a solidarity settlement was built in Vlasotince and new bridges were constructed in the villages Manastirište, Tegošnica, Stajkovac, Ravni Dol and Donji Dejan.

Severe rains and ensuing floods caused power outage in the entire municipality of Vlasotince and cut the supply of the drinking water.