Short-chain fatty acid

[citation needed] Derived from intestinal microbial fermentation of indigestible foods, SCFAs in human gut are acetic, propionic and butyric acid.

[1][2] SCFAs all possess varying degrees of water solubility, which distinguishes them from longer chain fatty acids that are immiscible.

[1][3] Macronutrient composition (carbohydrate, protein or fat) of diets affects circulating SCFAs.

[5] SCFAs and medium-chain fatty acids are primarily absorbed through the portal vein during lipid digestion,[6] while long-chain fatty acids are packed into chylomicrons, enter lymphatic capillaries, then transfer to the blood at the subclavian vein.

[1] SCFAs have diverse physiological roles in body functions, affecting the production of lipids, energy, and vitamins.