In 2003, Groysman graduated from the private higher education institution Interregional Academy of Personnel Management with a degree in law.

In the next 2010 election, Groysman was nominated by the political party Conscience of Ukraine and re-elected with substantial support, winning 77.8% of the vote.

[9] In December 2006, after signing a Memorandum of Understanding between the governments of Switzerland and Ukraine, Groysman promoted cooperation between Vinnytsia and Zurich.

Through co-financing, Vinnytsia installed water supply and sewage systems, repaired roads in residential areas, and maintained a landfill in Stadnytsia.

[23][22] That same year, the Verkhovna Rada adopted a resolution recognizing the European Parliament Mission’s recommendations as a basis for internal reform.

[26][27] During his early months as Prime Minister, Groysman was often described by journalists as lacking independence and closely connected to President Petro Poroshenko.

[33] In the first 100 days, Groysman met with European Council President Donald Tusk, German Chancellor Angela Merkel, U.S. Secretary of State John Kerry, and other Western political leaders.

[35] By 9 December he stated that local budgets had increased by 60% (UAH 44 billion) compared to the previous year, and that during the reform period in Ukraine, 184 consolidated territorial communities were established.

The government's plans included increasing income for Ukrainians, reducing the Pension Fund deficit, and encouraging economic recovery.

The civil service reform allowed for the selection of heads of regional and district state administrations, central executive bodies, and ministries based on a competitive process.

[46] On 1 April 2017, the "Affordable Medicines" program began, allowing for free or low-cost access to a number of medications, including treatments for cardiovascular disease, type 2 diabetes, and bronchial asthma.

[47][48] On 14 April 2017, marking his first year in office, Groysman highlighted his priorities, including stable economic growth, increased defense spending, decentralization, energy independence, and healthcare, pension, land, and education reforms.

[49] On 3 April the Cabinet finalized its 2020 action plan, consisting of five key points: 1) economic growth; 2) effective governance; 3) human capital development; 4) rule of law and anti-corruption efforts; and 5) security and protection.

The government’s plan aimed for a competitive economy and sustainable GDP growth of 4-5% per year, poverty reduction, and continued decentralization.

[60] Local communities gained the right to decide where to allocate these funds – on road repairs, construction of schools and hospitals, improvement of administrative services, establishment of new enterprises, etc.

Overall, passenger growth in the aviation sector reached 25-30% annually over the last three years, and the number of routes operated by budget airlines flying to Ukraine increased from 21 in 2016 to 89 in 2018.

On the government’s initiative, starting 1 September 2018, Ukrainian families receive a set of 25 essential items for newborns – a one-time aid known as the "baby package.

[73] On 20 May, during his inauguration speech, the 6th President of Ukraine, Volodymyr Zelenskyy, announced the dissolution of the Verkhovna Rada and called on the government to resign.

Ninety-seven deputies voted in favor of this decision, including members of Batkivshchyna, the Opposition Bloc, the Radical Party of Oleh Lyashko, and Samopomich.

[77][78] According to a survey by the Democratic Initiatives Foundation and the Razumkov Centre, in 2016, Groysman ranked second in the Politician of the Year rating after President Poroshenko.

[80] According to an all-Ukrainian poll by the Kyiv International Institute of Sociology (KIIS) in February 2019, Volodymyr Groysman led the list of those whom Ukrainians wanted to see as prime minister[81] after the presidential elections on 31 March 2019, but by May of that year, he was in fourth place (8.8%) according to a study by the Rating group.

[84] In July 2019, according to a poll by the "Rating" sociological group, nearly 30% of Ukrainians approved of Groysman's performance as prime minister (compared to 17% in March 2018[85]); however, more than 60% expressed dissatisfaction.

[95] In response, Poroshenko stated that Groysman's decision to participate in the parliamentary elections as a separate team was political suicide, but added that he held no grudges against him, although he did not approve of his choice.

[96] Since 2014, Groysman focused on national politics and occasionally appeared in public projects in Vinnytsia, including initiating the "Stop-Virus" fund to support and promote medical, preventive, and informational efforts to counter the spread of coronavirus.

Under Morgunov's leadership, Vinnytsia has held the position of the most comfortable city in Ukraine since 2015 (according to research by the International Republican Institute (IRI) in collaboration with the Rating sociological group).

In the first round of the mayoral election, Morgunov, the candidate from "Groysman's Ukrainian Strategy" and a long-time ally of the former prime minister, was re-elected with a significant lead, receiving 65.93% of the vote.

Following the full-scale Russian invasion of Ukraine, Groysman and his party paused political activities to focus on supporting the military, with Groysman in 2022 leading the Interregional Humanitarian Coordination Headquarters, which operates in two areas: aiding Ukrainian Armed Forces units and supporting the children of servicemembers and internally displaced persons.

"[103] In early July, the Basmanny District Court in Moscow issued an arrest warrant in absentia for Groysman, along with Klimkin, former Finance Minister Oleksandr Shlapak, and the commander of "Zakhid" Ihor Dovhan.

[104] “I eagerly await seeing all of them (Putin and other Russian criminals) on the dock, where they will answer for the innocent Ukrainians tortured and murdered, for the kidnapped and abused children.

His father, Borys Isakovych Groysman (born 1946), was a foreman at the Vinnytsia Radio Lamp Plant during Soviet times and has been an entrepreneur since 1990.