[1] As an actor, he is known for his role as Dr. Dennis Hancock on the CBS medical drama Chicago Hope created by David E. Kelley and as Ben Urich in the Netflix TV series Daredevil.

Curtis-Hall has appeared in numerous films including One Good Cop, Passion Fish, Sugar Hill, Coming To America, Crooklyn, Drop Squad, Eve's Bayou, Turn It Up and William Shakespeare's Romeo + Juliet.

His credits as a director include the films Gridlock'd, Glitter, Redemption: The Stan Tookie Williams Story,[2] Waist Deep, as well as episodes of television shows The Shield, Firefly, Chicago Hope, and MDs.

In 2000, Vondie Curtis-Hall and Danny Glover (who later portrayed Marty in the film adaptation of Dreamgirls) both appeared in the TNT made-for-television movie Freedom Song.

His most prominent television role as an actor to date is as supporting character Dennis Hancock on the medical drama Chicago Hope.