If the player manages to find, chase, and capture the Skull, it will increase the number of voodoo powers Vince can perform at one time.

Several levels differ from the standard gameplay the player experiences through the rest of the game and involve piloting a vehicle or playing a minigame.

Vince travels through the French Quarter of New Orleans, where he defeats a few enemies in his way such as a sleepy "Piggy Bank of Doom" and Reggie and Primo, two unruly gas pumps.

Inside, the floating head of Kosmo causes a dinosaur skeleton named "The Bone Goliath" to come to life and attack Vince.

After falling through the tunnel, Vince finds himself in the underground city of Roachfort, where he meets Professor Ethel, an egotistical turtle who is trying to make a balloon that will take them back to the surface.

After defeating the "obligatory boss battle" (a two-headed cyclopean alligator named Janice), Vince finds a tank of helium, which he uses to inflate himself and rise to the surface.

After a second meeting with Bones McMurty, defeating some monsters, putting some of the resident zombies to rest and destroying a massive statue brought to life by Kosmo, Vince travels to Brusque Manor.

The Manor is home to Dolly, a seemingly cute doll with a short temper who tells Vince that Madam Charmaine was taken to the Carnival DePrave.

But it turns out that the train is just a large model railroad set up, at which point Vince complains of his bad luck and his dealings with crazy people.

Dolly, feeling insulted and with help from Kosmo pulling the string behind her back, changes into a larger and more hideous doll and proceeds to attack Vince, destroying her toy city.

Crawdad Jimmy also offers to take Vince to the Carnival DePrave but asks him to collect some ingredients for his gumbo (onion, sausage, crawfish).

As the credits roll, Vince questions Madam Charmaine on why, if she's so powerful, she can't provide a decent home or even a second eye.

The remastered version improves the art assets, changes the loading screens (as well as shortens the time length), and leaves the gameplay untouched, although some of the audio in the game is either missing, cut suddenly, or replaced with different sounds.

[5] Dwellers Included gave Voodoo Vince: Remastered a 4.0 out of 5, saying "The game is oozing with charisma and character that fans, new and old, will be able to find both hilarious and challenging.