His parents were Jan IV of Pernštejn, Governor of Moravia and Count of Kladsko, and his second wife Hedwig of Schellenberg (Hedvika z Šelmberka).
Through court service and joint trips, including to Spain and Brussels, Vratislav maintained a close relationship of trust with Maximilian II.
[4][2] In 1560, he was sent to Madrid by Emperor Ferdinand I to congratulate the Spanish King Philip II on his marriage with Elisabeth of Valois.
In 1572, he was sent to Poland together with Wilhelm von Rosenberg, to unsuccessfully support the candidacy to the Polish throne of Archduke Ernest of Austria, Maximilian's son.
In Nové Město na Moravě, which experienced an economic boom during his reign, he had built the Renaissance town hall in 1555.
However, as it still belonged to the Protestants a year after his burial, his widow Maria de Lara decided to rebury his remains in St. Vitus Cathedral in Prague.