The Vuelta a Guatemala, which has become the largest sporting event in the country in terms of spectator affluence, was first held in 1957.

The winner of the first edition was local racer Jorge Surqué, and during the first four years, the competition was dominated by Guatemalan and Colombian participants.

From 1992 to 1996, five different Colombian participants took five consecutive titles, before local racer Luis Rodolfo Muj won in 1997, becoming the first Guatemalan to finish first since Edin Roberto Nova had won his second tour in 1988, and ending the longest drought of titles for his country.

The winner of the 2004 edition of the race, Lizandro Ajcú, was disqualified afterwards for doping in what was the biggest doping case of the race's history – nine riders including the first four on the General classification returned positive A samples.

Heavy rains during September and October damaged roads and paths, and the Guatemala Government, having concerns for life safety, decreed the cancellation as the infrastructure could not be restored in such a short period and rescheduling of the event was not feasible due to the busy schedules of different participants.