Unlike most heroes, Superman's adversaries exist in every known capacity; humans, metahumans, androids, sorcerers, empowered animals, other aliens (such as Kryptonians), mythical/supernatural creatures, corrupt doppelgängers of himself (imposters, clones, or parallel universe counterparts), interdimensional beings (Mr. Mxyzpltk, Vyndktvx), and even deities.
This event causes Luthor to snap and become a dangerous criminal and mad scientist who plots the destruction of Superman.
In the modern Post-Crisis era, Lex Luthor was re-envisioned as a wealthy CEO/scientist of LexCorp who hides his sociopathic tendencies behind a mask of philanthropy.
In the mainstream comic series, Luthor eventually manipulates his way to the U.S. Presidency, but is forcibly unseated from office by Superman and the Justice League.
In alphabetical order (with issue and date of first appearance): Post-Crisis: Miguel Diaz and Ray Ryker were two physicists until a nuclear experiment goes wrong.