Vyzas Megaron was founded in 1928 by students and named after the ancient Megara hero Byzas.

Vyzas played with Trikala, the 2nd team of the North group to the neutral stadium of Panionios at Nea Smyrni.

Vyzas was losing 1–0 till 90th minute where the Megara team had a genuine chance, which was stopped by a handball, as Megarians said, but the referee gave nothing.

At the 2009–2010 season Vyzas and Panachaiki were the two first teams of the South Group and was fighting for the first and the promotion to Beta ethniki.

Megara Stadium, the home ground of Vyzas is located in the centre of the city, and its capacity is 2,350.