Constructed in 1892, the structure was added to the National Register of Historic Places in 1980, and was designated a Mississippi Landmark in 2012.

[4] William James Quarles was a rural school teacher from Tennessee who settled in the Long Beach community of south Mississippi in 1884.

The Quarles House was constructed in 1892 as a five-bay, wood-frame, two-story residence with clapboard outer walls.

[5] Because the house was located on property that was highly prized for commercial development in Long Beach, the owner sought permission from the keeper of the National Register of Historic Places to move the structure approximately 400 feet (120 meters) northeast, near the Quarles Family Cemetery.

[4] In 1884, the cottage was originally part of a one-story house where the Quarles family resided while their new 2-story home was under construction.