By the early 1960s, he began attracting the attention of Texas blues performers such as Big Joe Turner, Albert Collins and Little Johnny Taylor.

[citation needed] From late September 1977 to May 1978, Clark played in an Austin blues quintet named Triple Threat Revue, with Stevie Ray Vaughan and Lou Ann Barton.

[citation needed] In 1990, Clark appeared on the PBS music television program Austin City Limits with his group W. C. Clark Blues Revue, from a show taped on October 10, 1989, in celebration of his 50th birthday, along with Stevie Ray Vaughan, Jimmie Vaughan and Kim Wilson of The Fabulous Thunderbirds, Lou Ann Barton, Angela Strehli and his former protégé Will Sexton.

[1] In March 1997, on the eve of Austin's South by Southwest music festival, as Clark and his band were returning from a show in Milwaukee, their van, driven by Clark, veered off the highway and down a steep embankment near Sherman, Texas, injuring his arm and killing his fiancée Brenda Jasek and his drummer Pedro Alcoser Jr.[3] The album Lover's Plea followed, containing the single "Are You Here, Are You There?

[4] In 2016, he appeared with his song "Rough Edges" on the album Texas Blues Voices by Italian harmonica player and Grammy Nominee Fabrizio Poggi.