[2] At Cambridge, he met Ronald McKerrow, whose friendship helped shape Greg's decision to pursue a career in literature.
In 1913 he held the Sandars Readership in Bibliography at Cambridge University lecturing on "Some bibliographical and textual problems of the English Miracle-play Cycles."
As an independent scholar, Greg produced editions of The Merry Wives of Windsor (1910), Robert Greene's Orlando Furioso and George Peele's The Battle of Alcazar (published together, 1923), and Sir Thomas More (1911).
He also wrote hundreds of reviews, including a notably caustic rejection of J. Churton Collins's 1905 Oxford edition of Robert Greene.
Greg was strongly associated with Alfred W. Pollard in developing a modern understanding of the transmission of Shakespeare's texts.