WEC 46: Varner vs. Henderson was a mixed martial arts event held by World Extreme Cagefighting on January 10, 2010.

[6] The Fabiano/Gomez bout was also rescheduled for WEC 49, where Fabiano won by unanimous decision.

Bantamweight contests pitting Eddie Wineland against Rafael Rebello and WEC newcomer George Roop against the returning Jesse Moreng were both scratched from this card after Rebello and Moreng both withdrew from the event.

[8] This was the last WEC card to feature former UFC Heavyweight Champion Frank Mir on color commentary.

He was officially replaced in April 2010 by Stephan Bonnar, who had filled in for Mir at WEC 47 due to training commitments.