The show was initially announced as taking place at the Stampede Corral in Calgary, Alberta, Canada.

[3] WEC vice-president Peter Dropick, however, confirmed with The StarPhoenix/Canwest News Service that the location was changed on April 10.

[5] Will Campuzano, who was previously scheduled to face Rafael Rebello on the preliminary card, was announced as Wineland's new opponent.

After WEC ring announcer Joe Martinez resigned to work for Golden Boy Promotions, fellow Zuffa-owned promotion UFC announcer Bruce Buffer agreed to handle fighter introductions for WEC 49.

[10] Kenny Florian would provide color commentary for the event, as he did at WEC 41 alongside play-by-play announcer Todd Harris.