WEC 53: Henderson vs. Pettis was a mixed martial arts event held by World Extreme Cagefighting that took place on December 16, 2010 at Jobing.com Arena in the Phoenix suburb of Glendale, Arizona.

[10] The winner of the WEC Lightweight Championship fight between reigning champion Benson Henderson and challenger Anthony Pettis was scheduled to face the winner of the UFC 125 Frankie Edgar (C) vs. Gray Maynard title fight in order to unify the WEC and UFC lightweight championships.

However, the Edgar/Maynard fight ended in a draw necessitating a UFC 136 rematch (which Edgar won).

Though Anthony Pettis won the final WEC lightweight title bout, defeating Henderson via unanimous decision, he opted not to wait for the winner of Edgar/Maynard rematch and instead fought Clay Guida at The Ultimate Fighter 13 Finale, losing by unanimous decision and negating his promised title shot (though he would win the UFC Lightweight Championship in his own right over Henderson in August 2013.)

Cruz defeated Jorgensen via unanimous decision to retain his title and become the new UFC champion.