In 1999, the station moved offices and studios from the basement of Clark Hall to its current location next the Wesleyan Argus on 45 Broad Street.

The university then announced its intention to seek an affiliation with National Public Radio (NPR), and to change the station's daytime format.

[7] WESU broadcasts with 6,000 watts effective radiated power (ERP), circular polarization, from the top of Wesleyan University's Exley Science Center in Middletown.

From Pacifica, it broadcasts Democracy Now!, Free Speech Radio News, The Ralph Nader Hour and Exploration in Science with Dr. Michio Kaku.

At the end of the episode "The Possimpible", Ted Mosby (played by Josh Radnor) is deleting his work experience at the radio station from his resume.