WEW's daily schedule consists entirely of programming provided by Overcomer Ministry featuring sermons from Brother Stair.

In late March 1921, the United States Weather Bureau, in conjunction with the SLU Department of Science, received permission from federal authorities to air informational broadcasts.

SLU president Reverend William Robison, S.J., made an introductory statement, then read a 500-word Weather Bureau bulletin.

[12] On August 22 livestock, grain and provision market reports were added to the broadcast schedule at 2 p.m. daily at 350 meters (857 kHz).

Weather reports aired at 10 a.m.[13] Initially there were no specific standards for stations making broadcasts intended for the general public.

Effective December 1, 1921, the Department of Commerce, which regulated radio at this time, adopted new guidelines that included a classification of "broadcasting stations".

Stations providing programs intended for the general public were now required to obtain a "Limited Commercial License" that included a broadcast service assignment.

SLU was issued its first broadcasting station authorization, for 485 meters, on March 23, 1922,[5] with the randomly assigned call letters WEW.

[14] WEW was the second Saint Louis station to receive a broadcasting authorization, following the Post-Dispatch's KSD (now KTRS), which had been licensed earlier that month.

On November 11, 1928, it settled on 760 kHz as part of a nationwide reallocation, under the Federal Radio Commission's implementation of General Order 40, now limited to daytime-only operation.

[16] It has also been suggested that the "Question Box Hour", a feature from 1923 described as "the first Catholic inquiry forum of the air", may qualify as the first radio quiz show.

[1] Unlike most early radio stations licensed to educational institutions, WEW continued to be operated by the university, despite the financial difficulties caused by the Great Depression.

In 1964, the station was purchased by Charles Stanley, who moved the studios to various locations, including the original Busch Stadium upon completion of the venue.

That is rare for one of the earliest radio stations in the U.S. Management has been trying to give WEW nighttime authorization and more than just 1,000 watts of power in the daytime.

On April 28, 2016, WEW was granted a Federal Communications Commission (FCC) construction permit to move to a new transmitter site.

However, numerous other stations, on both sides of the Mississippi River, have earlier establishment dates than WEW and even KDKA, when combined with their predecessor operations.