WISE-TV (channel 33) is a television station in Fort Wayne, Indiana, United States, affiliated with The CW Plus.

The two stations share studios on Butler Road in Northwest Fort Wayne, where WISE-TV's transmitter is also located.

The first person seen on television in Fort Wayne was Hilliard Gates, who served as the station's general manager and sports director until his retirement in 1990.

For a time, WKJG-TV was owned by Terre Haute industrialist Tony Hulman, best known as the longtime owner of the Indianapolis Motor Speedway.

A local marketing agreement was established that called for Granite to provide operation services to WPTA as well as for Malara's other new station, KDLH in Duluth, Minnesota.

MyNetworkTV was created in order to give UPN and WB stations, not mentioned as becoming CW affiliates, another option besides becoming independent.

WPTA decided to create a new second digital sub-channel to simulcast WBFW and offer access to CW programming for over-the-air viewers.

On September 5, WISE-TV moved NBC Weather Plus from its second digital subchannel in order for it to become the area's affiliate of MyNetworkTV.

After emerging from bankruptcy in the summer of 2007, Granite stock was taken over by Silver Point Capital of Greenwich, Connecticut, a privately owned hedge fund.

Silver Point immediately set about breaking up the company; many of its stations laid off employees or cut salaries up to 20%.

On February 11, 2014, Quincy Newspapers agreed to purchase WPTA from the Malara Broadcast Group as part of a deal to purchase Granite Broadcasting's stations in four markets (the other stations were KBJR-TV in Superior, Wisconsin, and its satellite KRII in Chisholm, Minnesota, WEEK-TV in Peoria, Illinois, and WBNG-TV in Binghamton, New York).

[4] In November 2014, the deal was reworked to remove SagamoreHill from the transaction; Quincy will now acquire WISE, with WPTA remaining with Malara.

On September 5, 2006, WISE-TV moved NBC Weather Plus programming to its third digital subchannel in order for WISE-DT2 to become the area's MyNetworkTV affiliate.

In June 2011, it was announced that WISE-DT2 would join Fox beginning August 1, 2011, taking the affiliation from then-current outlet WFFT-TV (owned by the Nexstar Broadcasting Group).

Upon the switch, the station shifted MyNetworkTV to secondary status on WISE-DT2 and began airing the two-hour weeknight programming block from 10:30 p.m. until 12:30 a.m.

Viewers did not react favorably and much of the negative feedback was given in "The Rant" section of The News-Sentinel where readers voiced their opinions.

Until 2013, newscasts on WISE-TV were practically identical to those on WPTA, which adopted Indiana's NewsCenter as a news brand for both stations.

When the stations upgraded to high definition in the fall of 2012, the INC brand was retired and WISE-TV simulcast WPTA newscasts in the interim.

On March 4, 2013, WISE-TV began producing its own newscast format from a secondary set adjacent to the WPTA newsroom studio.

Starting back on July 24, WISE-TV began airing a weeknight 10 o'clock newscast on its second digital subchannel that was an affiliate of NBC Weather Plus.

The station's signal is multiplexed: WISE-TV carried NBC Weather Plus on virtual channel 33.3 from 2006 until that network ceased operation on December 1, 2008.