It runs east–west in the southeastern part of the state from Hartford to Mequon and runs concurrently with Interstate 41/US Highway 41/US Highway 45 (I-41/US 41/US 45) in Germantown.

The highway was first numbered west of then-US 41 between 1939 and 1944 then extended to Mequon between 1948 and 1956.

[2] At the next freeway exit (exit 54), WIS 167 departs the freeway, running as a continuation of CTH-Y eastward as a divided highway until starting a short concurrency with WIS 145, after which it continues east into Ozaukee County and the city of Mequon.

The highway remains divided for the rest of its route, running concurrenctly with WIS 57 and intersecting CTH-W before ending at exit 85 on I-43; at that interchange, WIS 57 turns northward along I-43 and roadway continues eastward as Mequon Road.

[6][7][8] In 1983, the highway was rerouted in Germantown to a concurrency with US 41/US 45 west of the existing one with WIS 145 which had its length reduced significantly.