It was an NBC affiliate from the start but shared secondary ABC relations with WNCT until the 1963 sign-on of WNBE-TV (channel 12, now WCTI-TV) in New Bern.

In 1997, AFLAC sold its broadcasting group to Retirement Systems of Alabama which merged with Ellis Communications to form Raycom Media.

[5][6] As part of the SAFER Act, WITN-TV kept its analog signal on the air until June 26 to inform viewers of the digital television transition through a loop of public service announcements from the National Association of Broadcasters.

In addition to offering network and syndicated programming, WITN was also a multimedia rights partner for East Carolina University Athletics from 1998 to 2014.

In addition to hosting the weekly coaches' shows for football and basketball, the station produced live broadcasts of select games that were not picked up nationally by ESPN as part of its deal with Conference USA.

A further addition to that service occurred April 18, 2011, when it added MeTV and dropped all remaining weather-related programming with the new network taking up most of the weekend and daytime schedule.

Eventually, a new third digital subchannel signed on and began offering a 24-hour live feed of WITN's own Doppler weather radar.

[12] While broadcasting from its original facility in Chocowinity, WITN maintained secondary studios in Greenville on East Arlington Boulevard (within the Square Shopping Center) less than two blocks from its current base of operations.

After moving into its brand new facility in Greenville on June 5, 2013, WITN became the area's second television outlet to upgrade news production to high definition level.

[13] In addition to its main studios in Greenville, the station operates news bureaus in Jacksonville (on Valencia Drive) and in New Bern (on Middle Street).