The two stations share studios on DeBuys Road in Biloxi; WLOX's transmitter is located in unincorporated southern Stone County near McHenry.

In addition to bringing television to South Mississippi, WLOX also brought ABC programming to the western portion of the Mobile–Pensacola market.

That market's ABC affiliate, WEAR-TV in Pensacola, did not cover areas west of Mobile very well until cable arrived in the region in the 1970s.

Originally part of its Cosmos Broadcasting division, it came directly under the Liberty banner following the company's exit from the insurance business in 2000.

Under Raycom ownership and stricter ABC affiliate agreements, the station stopped removing network programming from its schedule due to content concerns.

WLOX created an award-winning two-disc DVD set about the storm entitled Katrina: South Mississippi's Story.

"[5] In 2006, WLOX received the Edward R. Murrow National Award in the category of continuing coverage for its around-the-clock broadcasting of Hurricane Katrina and the storm's aftermath.

In March 2012 during the station's 50th anniversary celebration, WLOX began airing a vague promotional advertisement alluding to having an "eye" on the future with the CBS "eyemark" logo in the background of the spot.

The station's front website banner also incorporated a "CBS—coming soon" link to the advertisement on YouTube suggesting a future digital subchannel with a schedule from the network for the market would be offered through WLOX.

[17][18] On December 30, 2023, WLOX parent company Gray Television announced it had reached an agreement with the New Orleans Pelicans to air 10 games on the station during the 2023–24 season.

[20] Among former WLOX employees is Chuck Scarborough who is currently the main co-anchor for WNBC in New York City and ABC's Good Morning America anchor Robin Roberts.

WLOX upgraded its local newscasts to high definition level on May 25, 2011, complete with a new set and updated corporate graphics from Raycom.

More specifically, WLOX's thirty-minute weekday afternoon show at 4, weeknight broadcast at 6, and weekend morning news are not seen on that second subchannel.