It was a mixed format station broadcasting classic rock, Broadway musicals, talk programs and more.
It eventually switched to opera and classical and then changed formats again in January 2009 to nearly exclusively jazz music.
Jazz hosts included Bob Protzman, Mark Richard, Helen Wigger, Tony Mowod, Bill Hillgrove.
WMCE is a broadcast service of Lake Erie College of Osteopathic Medicine (LECOM), said institution having purchased the station in 2018 from Mercyhurst University.
In May 2021, WMCE-FM purchased WWCB, a commercially licensed AM radio station based in Corry, Pennsylvania, from Bill Stafford.