It was also the first station in the United States to begin full-time multicast broadcasting when its HD-2 channel debuted on October 15, 2004.

From January 14, 2008, WOSU-FM switched to a mixed news/classical format, introducing NPR news magazines during morning and afternoon drive times along with several popular NPR weekend programs such as Weekend Edition, Car Talk, and Wait Wait... Don't Tell Me!, plus This American Life from Public Radio International.

Four of its satellite stations, WOSB in Marion, WOSE in Coshocton, WOSP in Portsmouth and WOSV in Mansfield were converted to repeaters of WOSA's classical format.

[4] These four stations, along with the newly-acquired WOSX in Granville, readded some of WOSU-FM's news programming, including Morning Edition, Weekend Edition, and All Things Considered, to their schedules on March 2, 2020, while continuing to simulcast WOSA for most of the day; the programming on WOSU-FM and WOSA did not change.

[5] Original programming on WOSU-FM includes daily two-hour public affairs show All Sides with Ann Fisher.