WTWO (channel 2) is a television station in Terre Haute, Indiana, United States, affiliated with NBC.

Malcolm Glazer sold WTWO and two of its sister stations, WRBL in Columbus, Georgia, and KQTV in St. Joseph, Missouri, to TCS Television Partners in 1990.

On July 9, 2012, Time Warner Cable replaced Cincinnati NBC affiliate WLWT with WTWO on its systems in southwestern Ohio and northeastern Kentucky, due to a carriage dispute with WLWT owner Hearst Television, that resulted in its stations being pulled from TWC's systems in several markets.

[9] WTWO made national news in January 2006 when it declined to air the controversial NBC dramedy series The Book of Daniel, citing calls and emails from viewers objecting to the show's plotline involving Jesus Christ as the rationale for its decision.

In a statement on the station's website, then-general manager Duane Lammers stated "our relationship with NBC always provided for the right to reject programming.

Unlike most NBC affiliates in the Eastern Time Zone, the station does not produce a midday newscast (but does provide local news inserts during NBC News Daily), or an early evening newscast at 5 p.m.; this is due to the fact that it produces such programs in those timeslots for sister station WAWV-TV, with channel 2 opting to run syndicated programming during the noon and 5 p.m. timeslots.

After WTWO entered into a joint sales agreement with Fox affiliate WBAK-TV, WTWO assumed production responsibilities for channel 38's half-hour primetime newscast at 10 p.m. on January 1, 2004, from WTHI (which had been producing the program since WBAK became the market's Fox affiliate in 1995), in addition to allowing the station to rebroadcast the 6 a.m. hour of channel 2's weekday morning newscast at 7 a.m.

[12] The promotion, though technically accurate, became a source of amusement on Comedy Central's The Daily Show because of its use of hyperbole and techniques reminiscent of political "attack ads".

[13] After general manager Duane Lammers called the Daily Show "hard-up for material" in a Tribune-Star article,[14] host Jon Stewart[15] mocked WTWO further in the following night's opening segment.

A response video to The Daily Show and Stewart that was supposed to be for internal uses at the station was leaked on YouTube; it has since been taken down, but was uploaded once more on iFilm.