The event took place on June 20, 2010, at the Nassau Coliseum in Uniondale, New York and featured wrestlers from the Raw and SmackDown brand divisions.

[3][4] The main feud for the Raw brand was a fatal four-way match for the WWE Championship between defending champion John Cena, Randy Orton, Edge, and Sheamus.

[7][8][9] The main event for the SmackDown brand was a fatal four-way match for the World Heavyweight Championship between Jack Swagger, Big Show, CM Punk, and Rey Mysterio.

[5] The Undertaker and CM Punk won their respective qualifying matches against Rey Mysterio and Kane.

A battle royal was put in place to determine The Undertaker's replacement in the match, which was won by Mysterio, who last eliminated Kane.

[5] On the May 17 episode, Gail Kim teamed up with Evan Bourne to defeat Alicia Fox and Zack Ryder.

[13] On the June 14 episode, the current Divas Champion, Eve, teamed up with Kim in a winning effort against Maryse and Fox and a fatal four-way match was announced between the four.

The WWE Divas Championship was defended next by Eve against Alicia Fox, Maryse, and Gail Kim in a fatal four-way match.

Mysterio took advantage of the situation and delivered the 619 to Swagger and covered him to win the World Heavyweight Title.

The match went at a quick pace throughout and ended when Miz reversed R-Truth for a pin attempt to retain the title.

In the main event, John Cena faced Sheamus, Randy Orton, and Edge in a fatal four-way match for the WWE Championship.

The match came to an abrupt end when the rookies from the first season of NXT who had previously formed a faction against the roster of the Raw brand, interrupted.

In the midst of the commotion, Sheamus pinned Cena to win the title, bringing the event to a premature conclusion.

Approximately 10,000 people attended Fatal 4-Way live at the Nassau Veterans Memorial Coliseum in Uniondale, New York.