[5] WrestleMania 2000 shares its game engine with the Japan-only release Virtual Pro Wrestling 2: Ōdō Keishō.

More than 50 WWF wrestlers were included in the game, and, with the exception of existing superstars' move sets, all of them can be freely edited to the player's liking.

Players are able to create a highly detailed wrestler with an extensive library of wrestling moves, many of which are carried over from previous AKI games in the series.

Starting out as a rookie, the player gradually works their way up the ladder and earns opportunities to gain various WWF titles, win various tournaments, be challenged by various wrestlers and ultimately main-event at WrestleMania 2000.

Throughout the mode, when the player wins a championship, they are expected to defend their title in future in-game pay-per-view events.

There are also arenas based on each WWF television show, such as Sunday Night Heat, Raw is War, as well as other pay-per-view venues of the time.

This was the first WWF game to allow players to freely edit their favorite superstars (i.e. putting Stone Cold Steve Austin in The Rock's trunks) and also be able to create and modify alternate attires for each wrestler, as each character in the game has four templates that can be individually edited and switched between using the left and right 'C' buttons.

Also, some taunts and move sets were carried over from WCW/nWo Revenge, allowing the player to create and include WCW wrestlers such as Goldberg, Kevin Nash, Scott Hall, Diamond Dallas Page, and Macho Man Randy Savage.

In WWF WrestleMania 2000, many players have their signature taunts, such as Stone Cold Steve Austin flipping off an opponent or Mr. Ass mooning another wrestler.

Some copies of WWF WrestleMania 2000 shipped with a special card containing four holograms of the in game action, such as a wrestler's entrance or finishing move.

"[22] Stuart Clarke of The Sydney Morning Herald said of the same console version: "The strong gameplay will even appeal to non-wrestling fans and with up to four people able to fight simultaneously it's sure to be a popular party game.

"[25][b] In another review, The D-Pad Destroyer called it "a very fun game, especially for four players, and its ease of play will endear it to hardcore wrestling fans who don't want to spend months studying a list of moves.