For this iteration, Wilson is a dishonorably discharged Special Forces operative and terminal cancer patient volunteering for an experimental treatment to awaken his latent mutant genes.

It gives him a regenerative healing factor that counteracts his illness but disfigures him, resulting in him adopting the moniker "Deadpool" (a name he borrows from his local dive bar's gambling system), killing the scientist responsible and reuniting with his fiancée Vanessa Carlysle.

The first film's success led to a sequel, Deadpool 2 (2018), in which Wilson forms the X-Force to protect a young mutant and avert his turn towards tyranny in the distant future.

After the successful opening weekend of Wolverine, Fox officially began development on Deadpool, with Reynolds attached to star and X-Men producer Lauren Shuler Donner involved.

The spinoff was set to ignore the Wolverine version of Deadpool and return to the character's roots with a slapstick tone and a "propensity to break the fourth wall".

[7] At Fox, the film went through several directors before Tim Miller settled on the position, with Rhett Reese and Paul Wernick hired to write the script.

[8] Due to this poor reception and the fact that a film based on Deadpool would most likely be rated R instead of PG-13, Fox became doubtful about the project, even after Reynolds produced test footage of himself in-character.

Only a few select people can withstand his seemingly endless talking, and his mouth is sewn shut in the final act of X-Men Origins: Wolverine.

In addition however, Wade bears similar personality traits to that of Agent Zero in X-Men Origins: Wolverine, being a ruthless killer as shown during Team X's mission in Nigeria where he sided with Stryker, Zero, and Creed when ordered to kill the inhabitants of the village.

Like his comics counterpart, Wade himself is aware that he is a fictional character and makes fun of this by breaking the fourth wall and speaking directly to the audience.

Despite his initial immaturity, Wade is a genuine, soft, good-hearted man, and in time becomes a very moral and heroic person to the point of sacrificing himself to save the mutant Russell Collins.

[25] In May 2022, screenwriter Michael Waldron confirmed in an interview that there had been discussions within Marvel regarding Reynolds making a cameo appearance as Deadpool in the multiverse-focused film Doctor Strange in the Multiverse of Madness (2022), as he himself felt "[it] would've been crazy to not raise that" after the inclusions of other X-Men related elements in the film such as the Savage Land and the character Professor Charles Xavier (played by returning X-Men actor Patrick Stewart).

[30] In the original continuity, Wade Wilson is a commando, mercenary, and Yale graduate with enhanced human reflexes and agility due to being a mutant.

Stryker has Wilson lobotomized and brainwashed into doing his bidding, giving him an adamantium skeleton like Logan's, including retractable blades in his forearms.

Unlike his counterpart in the comics, this name is conceived as Weapon XI has the powers of several mutants "pooled" into the dead body of Wade Wilson.

In a new continuity created through the aversion of the war between Sentinels, humans, and mutantkind,[b] Wilson is now a former Special Forces soldier who was dishonorably discharged, becoming a mercenary operating at Sister Margaret's School for Wayward Girls, where he meets and eventually proposes to hustler Vanessa Carlysle.

Driven partially insane by the ordeal and his disfigurement, Wade escapes and destroys the facility in the process, but ultimately loses to Ajax in battle.

Afraid to reunite with Vanessa in his current appearance, Wilson takes on the moniker "Deadpool", after remembering when his best friend Weasel bet in the Sister Margaret's group "dead pool" that he would die, and begins hunting for Ajax to force him to fix him.

They attempt to assault a convoy transferring Russell and several other Ice Box prisoners by parachuting from a plane, but the only survivors of the team end up being Wilson and Domino, a mutant whose powers pertain to luck.

The team is initially overpowered by Juggernaut while Russell terrorizes his headmaster until Colossus, Negasonic Teenage Warhead, and her girlfriend Yukio arrive and helped to hold him off.

Cable decides to use his final time-traveling charge to go back and hide Vanessa's Skee-Ball token inside Deadpool's uniform, in the spot where he would be shot.

Negasonic Teenage Warhead and Yukio manage to fix Cable's time-traveling device, and Wade uses it to make several alterations to the timeline.

After this, he makes a stop in the late 2000s to shoot Ryan Reynolds in the back of the head as he is reading the script for the film Green Lantern (2011), before traveling to Austria-Hungary in 1889 in order to care for a newborn Adolf Hitler and prevent his turn towards dictatorship.

Realizing that he would lose his friends and loved ones, Wade steals Paradox's TemPad and uses it to travel to Logan's grave, hoping to resurrect him and save their timeline.

When this fails, Wade kills several TVA agents sent by Paradox and uses the TemPad to travel the multiverse in search of an alternate universe "variant" of Logan that can replace his own.

Upon arriving at Nova's lair, she demonstrates her power to manipulate people's minds and explains her agreement with the TVA to stay in the Void as a gang leader.

Logan and Wade meet variants of Deadpool called "Nicepool" and "Dogpool", who give them a car and direct them towards a resistance group who have been fighting against Cassandra.

Similar to Wade Wilson in the original continuity, this version is a soldier and mercenary with enhanced human reflexes and agility and is a member of a black ops group called Team X under the command of William Stryker.

[53] Reynolds's initial portrayal of Wade Wilson / Deadpool / Weapon XI in X-Men Origins: Wolverine received significant critical and fan backlash.

Writing for the Huffington Post in an advance-screening review, Scott Mendelsohn panned the film's depiction of Deadpool and subsequent transformation into Weapon XI, amidst other characters featured in the film from the X-Men comics, affirming that "The climax, for reasons that I won't reveal, will absolutely infuriate devotees of [Deadpool] (for comparison, imagine if, at the end of Spider-Man 3, Eddie Brock turned into The Vulture)".